Quality and In Vivo Assessment of a Fulvic Acid Complex: A Validation Study

The present work aimed to re-assess the bioavailability enhancement potential of fulvic acid (FA). Carbamazepine (CBZ) and peat were used as a model drug FA source, respectively. Our group has already evaluated less commercially viable source FA, i.e., shilajit. In work, phase solubility CBZ was analyzed with varying concentrations peat-sourced (2–12% w/v). prepared complex (CBZ-FA) characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC). Dissolution, pharmacokinetic, pharmacodynamic studies also carried out. results showed presence an interaction between within complex, which led 98.99 ± 2.0% in solubility. 79.23 2.1% dissolution complexed over 60 min 69.32 2.2% permeation from intestinal gut sac 90 min, significant reduction duration epileptic seizures. Thus, this study re-authenticates our earlier suggests switching (shilajit peat) for commercial product development.